Samuel "Sam" Anders (Sean O'Neal) – Clarissa's best friend and confidant. Generally more optimistic and upbeat than she is, he often asks "What's the worst that can happen?"
He is perhaps best known for entering her second-story bedroom with a ladder after a distinctive guitar chord plays followed by Clarissa's "Hi, Sam" greeting. He is smart and polite and enjoys skateboarding. His parents are as mentioned in the pilot, divorced.